Mouse Anti-P2X7 Monoclonal Antibody (CBP2455)

Description

P2X purinoceptor 7 (P2RX7) is a member of the purinergic receptor P2X family. P2 purinergic receptors are cell surface receptors that are involved in proliferation of neural stem cells and have been implicated in learning, memory, and sleep. P2X receptors are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP binding. Functional P2X receptors are homo- or heterotrimeric complex composed of the P2X family members. P2RX7 functions as a ligand-gated cation channel and is responsible for synaptic transmission and ATP-dependent lysis of macrophages through the formation of membrane pores. P2RX7 is highly expressed in hematopoietic cells and is involved in cell death, host defense against pathogens, and the regulation of inflammatory responses. P2RX7 is also found in the nervous system, microglia, uterine endometrium, and the retina. Mutations in the P2RX7 gene have been associated to major depressive disorder (MDD) and low bone mineral density.

Immunogen

Partial human P2RX7 recombinant protein (43-334 a.a.) expressed in E. coli.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2455

Applications

WB

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

P2X7

Official Name

P2RX7

Full Name

P2RX7

Alternative Names

P2RX7; P2X7; purinergic receptor P2X 7

Gene ID

18439(Mouse)

Uniprot ID

Q9Z1M0(Mouse)

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4. Gavala ML, et al. 2013. J. Leuko. Biol. 94:759.
5. Notomi S, et al. 2011. Am. J. Pathol. 179:2798.
6. Lucae S, et al. 2006. Hum. Mol. Genet. 15:2438.