Mouse Anti-PIK3R1 Monoclonal Antibody (CBP2646)

Product Overview

Description

Phosphatidylinositol 3-kinase (PI3K) plays an important role in the metabolic actions of INS and is required for adipogenesis. The PI3K pathway has also been identified as an important player in cancer development and progression. The Class IA PI3K heterodimer, which is composed of a P110 catalytic subunit and a P85 regulatory subunit, is activated upon association of the P85 subunit with upstream adaptor proteins or receptor tyrosine kinases. Mutations in PIK3R1 are implicated in cases of breast cancer and associated to SHORT syndrome.

Expression Host

Mammalian cells

Immunogen

PI3 Kinase p85 Alpha fusion protein Ag2344

Species Reactivity

Human; Mouse; Porcine; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2646

Applications

IP; WB; ELISA

Application Notes

IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PIK3R1

Official Name

PIK3R1

Full Name

Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Alternative Names

GRB1; p85; p85 ALPHA; PI 3 Kinase p85 alpha; PI 3-kinase p85α; PI3 kinase subunit p85 alpha; PI3K p85(alpha)

Gene ID

5293(Human); 18707(Mouse); 366508(Rat)

Uniprot ID

O00329(Human); O35904(Mouse)

References

1. Zeng, Z. S., Lin, J., Xu, C. B., Cao, L., Chen, C., & Li, J. (2019). Minimally modified low-density lipoprotein upregulates the ETB and α1 receptors in mouse mesenteric arteries in vivo by activating the PI 3K/Akt pathway. Journal of Pharmacy and Pharmacology, 71(6), 937-944. 2. Dong, X., Yang, Y., Zhou, Y., Bi, X., Zhao, N., Zhang, Z.,... & Cao, P. (2019). Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy. Cell Death & Differentiation, 26(10), 2086-2099. 3. Guo, Y., & Pei, X. (2019). Tetrandrine-induced autophagy in MDA-MB-231 triple-negative breast cancer cell through the inhibition of PI3K/AKT/mTOR signaling. Evidence-Based Complementary and Alternative Medicine, 2019.

Publications