Mouse Anti-TP53 Monoclonal Antibody (CBP2655)

Product Overview

Description

P53 is a tumor suppressor gene that plays a role in maintaining genomic stability and controlling apoptosis. During the cell cycle, it can arrest cells at the G1/S checkpoint and activate DNA repair mechanisms. It is the most mutated gene in cancer. In unstressed cells, p53 usually exists at low levels in an inactive form, being bound to Mdm2.

Expression Host

Mammalian cells

Immunogen

P53 fusion protein Ag0698

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2655

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TP53

Official Name

TP53

Full Name

Tumor protein p53

Alternative Names

Antigen NY CO 13; Cellular tumor antigen p53; FLJ92943; LFS1; P53; Phosphoprotein p53; TP53; TRP53

Gene ID

94241(Human); 60599(Mouse); 297822(Rat)

Uniprot ID

Q96A56(Human); Q9QXE4(Mouse); Q80YE2(Rat)

References

1. Zeng, Q., Zhang, Y., Zhang, W., & Guo, Q. (2020). Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition. Molecular Medicine Reports, 21(6), 2544-2552. 2. Li, S., Han, J., Guo, G., Sun, Y., Zhang, T., Zhao, M.,... & Zhang, J. (2020). Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS letters, 594(3), 497-508. 3. Feng, Q., Bian, X., Liu, X., Wang, Y., Zhou, H., Ma, X.,... & Zheng, Z. (2020). Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy. BMC cancer, 20(1), 1-13.

Publications