Mouse Anti-PTEN Monoclonal Antibody (CBP2660)

Product Overview

Description

PTEN are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors, such as brain, breast, kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.

Expression Host

Mammalian cells

Immunogen

PTEN fusion protein Ag17274

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2660

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PTEN

Official Name

PTEN

Full Name

Phosphatase and tensin homolog

Alternative Names

10q23del; BZS; MHAM; MMAC1; phosphatase and tensin homolog; PTEN; PTEN1; TEP1

Gene ID

5728(Human); 19211(Mouse); 50557(Rat)

Uniprot ID

P60484(Human); O08586(Mouse)

References

1. He, T., Liu, Y., Zhao, S., Liu, H., Wang, Z., & Shi, Y. (2019). Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome. European Journal of Obstetrics & Gynecology and Reproductive Biology, 233, 134-140. 2. Guo, Y., & Pei, X. (2019). Tetrandrine-induced autophagy in MDA-MB-231 triple-negative breast cancer cell through the inhibition of PI3K/AKT/mTOR signaling. Evidence-Based Complementary and Alternative Medicine, 2019.

Publications