Mouse Anti-BEST1 Monoclonal Antibody (CBP2668)

Product Overview

Description

Bestrophin-1 (BEST1) belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).

Expression Host

Mammalian cells

Immunogen

Bestrophin-1 fusion protein Ag15129

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2668

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neuron

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

780 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

BEST1

Official Name

BEST1

Full Name

Bestrophin 1

Alternative Names

ARB;
BEST 1;
BEST;
Best disease;
Best macular dystrophy;
BEST1;
BEST1_HUMAN;
Best1V1Delta2;
Bestrophin 1;
Bestrophin-1;
Bestrophin1;

Gene ID

7439(Human)

Uniprot ID

O76090(Human)

References

1. Hsu, K. S., Otsu, W., Li, Y., Wang, H. C., Chen, S., Tsang, S. H.,... & Sung, C. H. (2019). CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific reports, 9(1), 1-17.

Publications