Mouse Anti-ENO2 Monoclonal Antibody (CBP2701)

Product Overview

Description

NSE, also named as ENO2, belongs to the enolase family. Enolases are cytoplasmic glycolytic enzymes that may be involved in differentiation. The enolase has three isoenzymes, alpha, beta and gamma. The alpha form is expressed in most tissues, whereas the beta form is expressed in muscle tissue. The gamma enolase (ENO2), a homodimer, is primarily localized in neurons and neuroendocrine cells and is a cancer diagnostic marker for brain tumors (PMID:7520111). ENO2 plays a role in the glycolysis-related energy pathway and might be involved in higher metabolic activity during the day than at night, at least in part.

Expression Host

Mammalian cells

Immunogen

NSE fusion protein Ag19106

Species Reactivity

Human; Mouse; Rat; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2701

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NSE

Official Name

ENO2

Full Name

Enolase 2 (gamma, neuronal)

Alternative Names

Enolase 2; enolase 2 (gamma; neuronal); Gamma enolase; Neural enolase; Neuron specific enolase; NSE; NSE/ENO2-specific

Gene ID

2027(Human); 13806(Mouse); 24333(Rat)

Uniprot ID

P13929(Human); P17182(Mouse); P04764(Rat)

References

1. Xu, C., Wang, C., Meng, Q., Gu, Y., Wang, Q., Xu, W.,... & Xu, J. (2019). miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase. Molecular medicine reports, 20(2), 1725-1735.

Publications