Mouse Anti-CDH2 Monoclonal Antibody (CBP2719)

Product Overview

Description

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a 130-kDa transmembrane protein and a classical member of the cadherin superfamily which also include E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes.

Expression Host

Mammalian cells

Immunogen

N-cadherin fusion protein Ag4996

Species Reactivity

Human; Porcine; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2719

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neurotransmission

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

N-Cadherin

Official Name

CDH2

Full Name

Cadherin 2, type 1, N-cadherin (neuronal)

Alternative Names

Cadherin 2;
Cadherin 2 N cadherin neuronal;
Cadherin 2 type 1;
Cadherin 2 type 1 N cadherin neuronal;
Cadherin 2; type 1; N-cadherin (neuronal);
Cadherin-2;
Cadherin2;
Calcium dependent adhesion protein neuronal;
CD325;

Gene ID

1000(Human); 12558(Mouse); 83501(Rat)

Uniprot ID

P19022(Human); P15116(Mouse); Q9Z1Y3(Rat)

References

1. Jiang, X., Du, Y., Meng, X., Zhang, H., Zhao, D., Zhao, L.,... & Jiang, H. (2018). Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin. Dose-Response, 16(4), 1559325818813061. 2. Xie, C., Zhu, J., Wang, X., Chen, J., Geng, S., Wu, J.,... & Li, X. (2019). Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13. 3. Lv, S., Wang, N., Lv, H., Yang, J., Liu, J., Li, W. P.,... & Chen, Z. J. (2019). The attenuation of trophoblast invasion caused by the downregulation of EZH2 is involved in the pathogenesis of human recurrent miscarriage. Molecular Therapy-Nucleic Acids, 14, 377-387.

Publications