Anti-RCAN1 Monoclonal Antibody (CBP3734)

Product Overview

Description

RCAN1 is a protein that inhibits the calcineurin/NFAT signaling pathway via it's interaction with calcineruin A. RCAN1 has three different transcript variants, among which RCAN1.4 has been shown to regulate gene expression, cell migration and tubular morphogenesis in endothelial cells. Dysfunction of RCAN1 has been reported to impact the development of central nervous system, and is clinically linked to Down syndrome. It has also been reported that chronic overexpression of RCAN1 leads to formation of neurofibrillary tangles (NFT), and thus may play a role in neurodegenerative diseases such as AD.

Immunogen

Recombinant human RCAN1

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3734

Applications

Application Notes

WB (2-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

RCAN1

Official Name

RCAN1

Full Name

Regulator Of Calcineurin 1

Alternative Names

Regulator Of Calcineurin 1; Myocyte-Enriched Calcineurin-Interacting Protein 1; Down Syndrome Critical Region Gene 1; Calcipressin-1; ADAPT78; DSCR1; MCIP1; CSP1; DSC1; Modulatory Calcineurin-Interacting Protein 1; Down Syndrome Critical Region Protein 1; Calcium And Oxidant-Inducible MRNA; Down Syndrome Candidate Region 1; Near DSCR Proline-Rich Protein; Adapt78; RCN1

Gene ID

1827 (Human); 54720 (Mouse); 266766 (Rat)

Uniprot ID

P53805 (Human); Q9JHG6 (Mouse); Q6IN33 (Rat)

References

1. Porta S, et al. 2007. Hum Mol Genet. 16(9):1039
2. Torac E, et al. 2014. J Med Life. 7(4):481
3. Wu Y, et al. 2014, Mol Neurobiol. 50(3):1085
4. Harris CD, et al. 2005. Cell Mol Life Sci. 62(21):2477

Publications