Rat Anti-Human CCL4 Monoclonal Antibody (CBP3756)

[CAT#: NAB2012144LS]

Anti-CCL4 Monoclonal Antibody

Host Species:: Rat

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

CCL5, also known as RANTES, is a 7.8 kD member of the CC family of chemokines, which is expressed in T cells and monocytes/macrophages. CCL5 is strongly chemotactic for monocytes/macrophages, memory T cells, eosinophils, and induces histamine release from basophils. In a solution, RANTES can form high molecular weight aggregates that exhibit dissimilar biological activities to its dimeric form. The aggregates cause T cell and neutrophil activation while promoting HIV infection, whereas the dimeric form exhibits RANTES-induced chemotaxis and inhibits HIV infection. As T cells become activated, RANTES secretion appears to decrease.

Immunogen

Partial human CCL4 recombinant protein (24-92 a.a.) expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP3756

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CCL4

Official Name

CCL4

Full Name

C-C motif chemokine 4

Alternative Names

C-C motif chemokine 4; MIP-1-beta; Act-2; Protein H400; Small-inducible cytokine A4; ACT2; MIP-1B; Macrophage inflammatory protein 1-beta; Immune activation protein 2; SIS-gamma; ACT-2; Mip1b; Scya4; AT744.1

Publications