Product
Rat Anti-Human CCL4 Monoclonal Antibody (CBP3756)
[CAT#: NAB2012144LS]
Anti-CCL4 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
CCL5, also known as RANTES, is a 7.8 kD member of the CC family of chemokines, which is expressed in T cells and monocytes/macrophages. CCL5 is strongly chemotactic for monocytes/macrophages, memory T cells, eosinophils, and induces histamine release from basophils. In a solution, RANTES can form high molecular weight aggregates that exhibit dissimilar biological activities to its dimeric form. The aggregates cause T cell and neutrophil activation while promoting HIV infection, whereas the dimeric form exhibits RANTES-induced chemotaxis and inhibits HIV infection. As T cells become activated, RANTES secretion appears to decrease.
Immunogen
Partial human CCL4 recombinant protein (24-92 a.a.) expressed in E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP3756
Applications
WB
Application Notes
WB (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CCL4
Official Name
CCL4
Full Name
C-C motif chemokine 4
Alternative Names
C-C motif chemokine 4; MIP-1-beta; Act-2; Protein H400; Small-inducible cytokine A4; ACT2; MIP-1B; Macrophage inflammatory protein 1-beta; Immune activation protein 2; SIS-gamma; ACT-2; Mip1b; Scya4; AT744.1
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
