Mouse Anti-Human CD138 Monoclonal Antibody (CBP3851)

Product Overview

Description

CD138, a member of the syndecan protein family, is a type I integral membrane heparin sulfate proteoglycan. CD138 is also known as Syndecan-1. CD138 participates in cell proliferation, cell migration, and cell-matrix adhesion via interaction with collagen, fibronectin, and other soluble molecules (such as FGF-basic). It is expressed on normal and malignant human plasma cells, pre-B cells, epithelial cells, and endothelial cells, but not on mature circulating B-lymphocytes. It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial cells, and neural cells.

Immunogen

A mixture of U266 and XG-1 human myeloma cell lines.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3851

Applications

FC; ICC; WB; IHC-P

Application Notes

FCM (≤ 0.5 µg per million cells in 100 µL volume)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD138

Official Name

SDC1

Full Name

Syndecan 1

Alternative Names

SDC1; CD138; SDC; SYND1; syndecan; syndecan 1

Gene ID

6382(Human); 20969(Mouse); 25216(Rat)

Uniprot ID

P18827(Human); P18828(Mouse); P26260(Rat)

References

1. Sanderson RD, et al. 1992. Cell. Regul. 1:27.
2. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers. Wiley-Liss A John Wiley & Sons Inc, Publication

Publications