Anti-Synaptobrevin Monoclonal Antibody (CBP3944)

Product Overview

Description

Synaptobrevins, also known as VAMPs, along with syntaxins and the synaptosomal-associated protein SNAP25, form the protein complex that is involved with the docking and fusion of synaptic vesicles with the presynaptic membrane. Synaptobrevins have a molecular weight of 18 kD, and are also involved in the formation of the SNARE complexes. The synaptobrevins are degraded by the protein tetanospasmin, from the tetanus-causing bacterium Clostridium tetani, as well as botulinum toxin from Clostridium botulinum.

Immunogen

A crude synaptic preparation of post mortem human brain.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgM

Clone Number

CBP3944

Applications

WB; IHC-P; ELISA; ICC

Application Notes

WB (1:1000-1:2000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

Ascites Fluid (contains 0.01M sodium azide).

Concentration

Batch Dependent

Purification

Unpurified

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at-20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Synaptobrevin

Official Name

Synaptobrevin

Full Name

Synaptobrevin

Alternative Names

PROM1

References

1. Zhang L, et al. 2018. Medicine (Baltimore). 97(29):e11487
2. Moris, et al. 2018. Anticancer res. 38(2):601
3. Hami J, et al. 2017. J pediatr Neurosci. 12(3):215

Publications