Product
Rat Anti-Mouse CD186 Monoclonal Antibody (CBP3962)
[CAT#: NAB2012893LS]
Anti-CD186 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Mouse
- Applications:
- FC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
CD186, also konwn as CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. Its ligand is CXCL16. It is expressed on different T cell subsets and is upregulated in activated T cells. Expression of CXCR6 is correlated with increased inflammatory responses and seems to contribute to liver fibrosis.
Immunogen
mCXCR6-transfectants
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2b, κ
Clone Number
CBP3962
Applications
FC
Application Notes
FCM (≤0.5 µg per million cells in 100 µL volume)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
0.2 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CD186
Official Name
CXCR6
Full Name
Chemokine receptor CXCR6
Alternative Names
C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186). CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells; in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1; nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV; CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
