Rat Anti-Mouse CD186 Monoclonal Antibody (CBP3962)

[CAT#: NAB2012893LS]

Anti-CD186 Monoclonal Antibody

Host Species:: Rat

Species Reactivity:: Mouse

Applications:: FC

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Product Overview

Description

CD186, also konwn as CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. Its ligand is CXCL16. It is expressed on different T cell subsets and is upregulated in activated T cells. Expression of CXCR6 is correlated with increased inflammatory responses and seems to contribute to liver fibrosis.

Immunogen

mCXCR6-transfectants

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP3962

Applications

Application Notes

FCM (≤0.5 µg per million cells in 100 µL volume)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

0.2 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD186

Official Name

CXCR6

Full Name

Chemokine receptor CXCR6

Alternative Names

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186). CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells; in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1; nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV; CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.