Mouse Anti-Human AKT1 Monoclonal Antibody (CBP3988)

Product Overview

Description

AKT (Protein Kinase B, PKB) is a serine/threonine kinase that plays a key role in regulating cell proliferation, survival and metabolism. AKT disorders can lead to diseases such as cancer, diabetes, and cardiovascular and neurological diseases. There are three isotypes of AKT-AKT1, 2 and 3 (also called PKBα, β and γ). AKT is activated by oncogenic mutations in growth factors and other extracellular stimuli, as well as key upstream regulatory proteins (including Ras, PI3-kinase subunits, and PTEN). More and more evidences show that AKT1, 2 and 3 play a unique role in the occurrence and development of breast cancer. AKT1 has a cardioprotective effect on the heart by supporting its physiological growth and function. When conducting postmortem brain studies on patients with schizophrenia in many countries, it was found that AKT1 levels in the frontal cortex were reduced.

Immunogen

Full length recombinant protein of human AKT1 expressed in HEK293T cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3988

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

AKT1

Official Name

AKT1

Full Name

AKT Serine/Threonine Kinase 1

Alternative Names

AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;