Mouse Anti-Human Bcl-2 Monoclonal Antibody (CBP3990)
[CAT#: NAB2012987LS]
Anti-Bcl-2 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Bcl-2 is a conservative anti-apoptotic protein, which plays an important role in normal immunity. It forms homodimers or heterodimers with other members of the Bcl-2 family. This protein regulates cell apoptosis by controlling mitochondrial fusion and fission. It has been shown that phosphorylation of Bcl-2 can enhance activity in response to signals mediated by extracellular growth factors. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Bcl-2 chromosome 18q21.3 translocation and overexpression are often observed in follicular lymphoma and some diffuse large B-cell lymphomas.
Immunogen
Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP3990
Applications
WB
Application Notes
WB (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Data
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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