Mouse Anti-Human WNT3A Monoclonal Antibody (CBP4260)

Product Overview

Description

Wnt3a, one of Wnt family members, plays a key role in carcinogenesis. Studies have shown that Wnt3a can both promote and suppress cancer progression depending on the cancer type. Mechanistically, Wnt3a activates downstream signaling pathways in a canonical manner by binding to its receptor Frizzled (Fz) and co-receptor lipoprotein receptor-related proteins 5/6 (LRP5/6), which ultimately promote nuclear translocation of the transcription factor b-catenin. Wnt3A is also involved in non-oncogenic pathways. It modulates brain-derived insulin by increasing NeuroD1 expression levels. Following traumatic brain injury, Wnt3A secreted by mesenchymal stem cell was shown to be neuroprotective and promote neurocognitive recovery.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4260

Applications

Application Notes

WB (0.2-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.