NoGeneST™ Anti-Nucleolin Aptamer, aNucleolin aptamer-2 Triethylamine

Name: NoGeneST™ Anti-Nucleolin Aptamer, aNucleolin aptamer-2 Triethylamine
SKU: NRYF-0625-HZ20
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ20]

A G-quadruplex DNA aptamer that targets the protein nucleolin, functioning as a direct-acting anticancer agent.

Target:: NCL

Type:: DNA

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Product Overview

Description

This is a 26-base, guanine-rich single-stranded DNA aptamer that self-assembles into a highly stable G-quadruplex structure. It acts as an anticancer agent by binding with high affinity and specificity to nucleolin, a protein that is aberrantly overexpressed on the surface of many types of cancer cells. This binding disrupts the multiple oncogenic functions of nucleolin, leading to the inhibition of cancer cell proliferation and the induction of apoptosis.

Type

DNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

NCL

Full Name

Nucleolin

Alternative Names

C23; Nsr1

Gene ID

4691

Uniprot ID

P19338

Target Overview

Nucleolin (NCL) is a highly abundant, multifunctional phosphoprotein found primarily in the nucleolus of growing eukaryotic cells. It is critically involved in multiple stages of ribosome biogenesis, including the transcription of ribosomal DNA (rDNA), maturation and processing of pre-rRNA, and the assembly of ribosomal subunits. Beyond the nucleolus, Nucleolin shuttles to the cytoplasm and can also be found on the cell surface, where it acts as a receptor for various ligands. Due to its overexpression on the surface of cancer cells and its central role in cell proliferation, survival, and growth, Nucleolin has become a key therapeutic target in oncology.

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