NoGeneST™ Anti-Nucleolin Aptamer, aNucleolin aptamer-1 sodium

Name: NoGeneST™ Anti-Nucleolin Aptamer, aNucleolin aptamer-1 sodium
SKU: NRYF-0625-HZ8
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ8]

Anti-tumor activity

Target:: NCL

Type:: DNA

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Product Overview

Description

This product is an advanced, synthetically-derived aptameric agent engineered for high-affinity engagement with Nucleolin (NCL). Structurally, it is a 26-base guanine-rich oligonucleotide that spontaneously folds into a stable G-quadruplex conformation. This unique three-dimensional structure is fundamental to its biological function, enabling it to act as a potent antagonist to Nucleolin's oncogenic activities. Its primary application is in cancer research, where it serves as a powerful tool to induce anti-proliferative effects and explore novel therapeutic pathways.

Type

DNA

Relevant Diseases

Cancer

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

NCL

Full Name

Nucleolin

Alternative Names

C23; Nsr1

Gene ID

4691

Uniprot ID

P19338

Target Overview

Nucleolin (NCL) is a highly abundant, multifunctional phosphoprotein found primarily in the nucleolus of growing eukaryotic cells. It is critically involved in multiple stages of ribosome biogenesis, including the transcription of ribosomal DNA (rDNA), maturation and processing of pre-rRNA, and the assembly of ribosomal subunits. Beyond the nucleolus, Nucleolin shuttles to the cytoplasm and can also be found on the cell surface, where it acts as a receptor for various ligands. Due to its overexpression on the surface of cancer cells and its central role in cell proliferation, survival, and growth, Nucleolin has become a key therapeutic target in oncology.

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