NoGeneST™ Anti-Parkin Aptamer, aParkin aptamer

Name: NoGeneST™ Anti-Parkin Aptamer, aParkin aptamer
SKU: NRYF-0625-HZ93
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ93]

Aptamer designed to specifically recognize Parkin, an E3 ubiquitin ligase critical for mitochondrial quality control and implicated in Parkinson's disease.

Target:: Parkin

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Product Overview

Relevant Diseases

Parkinson's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

Parkin

Full Name

E3 Ubiquitin-Protein Ligase Parkin

Alternative Names

PRKN

Gene ID

5071

Uniprot ID

O60260

Target Overview

Parkin is a crucial E3 ubiquitin ligase, an enzyme that attaches ubiquitin tags to other proteins to mark them for degradation by the cell's proteasome system. It plays a vital role in cellular quality control, most notably in a process called mitophagy, which is the selective clearance of damaged or dysfunctional mitochondria. Loss-of-function mutations in the PARK2 gene, which codes for the Parkin protein, are the most common cause of autosomal recessive, early-onset Parkinson's disease. The resulting failure of the mitophagy pathway is thought to lead to the accumulation of toxic, damaged mitochondria and subsequent death of dopamine-producing neurons.

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