Creative Biolabs

Rat Anti-Human Myelin Basic Protein Monoclonal Antibody (Clone L-S-129)

[CAT#: NAB2010222LS]

Anti-Myelin Basic Protein Monoclonal Antibody

Host Species:
Rat
Species Reactivity:
Human
Applications:
WB

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Description
Myelin basic protein (MBP) is a protein involved in the myelination of nerves in the central nervous system (CNS). MBP functions to maintain the correct structure of myelin, through its interaction with the lipids in the myelin membrane. The myelin sheath is made up of MBP and lipids, and acts as an insulator to increase the velocity of axonal impulse conduction. MBP plays a central role in the demyelinating disease multiple sclerosis (MS). A hallmark of the disease is the loss of the myelin sheath surrounding nerves, thought to be induced by antibodies against MBP.
Immunogen
Synthetic peptide corresponding to human MBP amino acids 82-87
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
L-S-129
Applications
WB
Application Notes
WB (0.1-0.5 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Myelin Basic Protein
Official Name
MBP
Full Name
Myelin basic protein
Alternative Names
MBP; entrez:4155; myelin basic protein; Myelin basic protein; Myelin_BP; IPR000548
Gene ID
4155(Human); 17196(Mouse); 24547(Rat)
Uniprot ID
P02686(Human); P04370(Mouse); P02688(Rat)
1. Llyasov AA, et al. 2018. Front Neurosci. 12:733
2. Muller C, et al. 2013. Front Cell Neurosci. 7:169
3. Harauz G, et al. 2013. J Neurochem. 125(3):334
Neural Genes
Neural Antibodies
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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