SOD1 shRNA Plasmid Expression Vector Set

Name: SOD1 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY342
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY342]

Target:: SOD1

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Product Overview

Description

A powerful kit for the specific knockdown of the Superoxide Dismutase 1 (SOD1) gene, a primary cause of familial ALS. The set includes three sequence-verified shRNA plasmid vectors, each targeting a different region of the SOD1 mRNA for high knockdown efficiency, along with a non-targeting scrambled shRNA plasmid as a negative control. It is a fundamental tool for studying the toxic gain-of-function of mutant SOD1.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

SOD1

Full Name

Potassium Voltage-Gated Channel Subfamily KQT Member 2

Alternative Names

Kv7.2; EBN1; BFNC

Gene ID

3785

Uniprot ID

O43526

Target Overview

KCNQ2 is a voltage-gated potassium channel subunit that is crucial for regulating neuronal excitability. It co-assembles with the related KCNQ3 subunit to form the channel that generates the "M-current," a slow, non-inactivating potassium current. This M-current acts as a powerful brake on repetitive neuron firing, thereby stabilizing the membrane potential and preventing hyperexcitability. Loss-of-function mutations in the KCNQ2 gene are a primary cause of neonatal epileptic encephalopathies, as the resulting impairment of the M-current leads to severe seizures.

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