C4A shRNA Plasmid Expression Vector Set

Name: C4A shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY367
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY367]

Target:: C4A

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Product Overview

Description

A powerful tool for the specific knockdown of the Complement Component 4A (C4A) gene, a major genetic risk factor for schizophrenia. The set includes three distinct shRNA plasmid vectors targeting C4A mRNA, plus a scrambled shRNA plasmid as a negative control. It allows researchers to investigate the role of C4A in excessive synaptic pruning and the developmental origins of schizophrenia.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

C4A

Full Name

Disrupted In Schizophrenia 1 Protein

Gene ID

27185

Uniprot ID

Q9RIA5

Target Overview

Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein that plays a critical role in the brain by coordinating a wide range of signaling pathways essential for neurodevelopment. Its functions include regulating neuronal proliferation, differentiation, migration, and synaptic integration. The DISC1 gene was famously identified through its disruption by a chromosomal translocation in a Scottish family with a high incidence of major mental illness. It has since become one of the most significant and widely studied genetic risk factors for a spectrum of severe psychiatric disorders, including schizophrenia, bipolar disorder, and major depression.

Publications