Creative Biolabs

Human Anti-Mouse Apo E 154-162 Monoclonal Antibody (Clone A17065A), Conjugated

[CAT#: NAB201272LS]

Anti-Apo E 154-162 Monoclonal Antibody [Biotin]

Host Species:
Human
Species Reactivity:
Mouse
Applications:
WB

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Lot Number

Description
Apolipoprotein E (ApoE) belongs to a class of apolipoproteins, which combine with lipids to form lipoproteins. ApoE is produced by macrophages in the liver and peripheral tissues and can regulate cholesterol metabolism. In the central nervous system, ApoE is mainly produced by astrocytes and plays an important role in transporting cholesterol to neurons through ApoE receptors. ApoE has three main isoforms corresponding to the three alleles (ApoE2, ApoE3 and ApoE4), which differ by only one or two amino acids at positions 112 and 158. ApoE4 is known to be one of the largest genetic risk factors for advanced Alzheimer's disease. In addition, ApoE4 is also associated with several other diseases, such as atherosclerosis, cognitive impairment and multiple sclerosis.
Immunogen
KLH conjugated Apo E peptide encompassing amino acids 154-162.
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Human
Isotype
IgG2b, κ
Clone Number
A17065A
Applications
WB
Application Notes
WB (1.0-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Apo E
Official Name
APOE
Full Name
Apolipoprotein E
Alternative Names
APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4
Gene ID
348 (Human); 11816 (Mouse)
Uniprot ID
P02649 (Human); P08226 (Mouse)
1. Mahley RW. 2016. Arterioscler Thromb Vasc Biol. 36: 1305-1315.
2. Riedel BC, et al. 2016 J Steroid Biochem Mol Biol. 160:134-47.
3. Tai LM, et al. 2016 Acta Neuropathol. 131(5):709-23.
4. Kim J, et al. 2014. Mol. Cells. 37:767
5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312
Neural Antibodies
Neural Proteins & Peptides
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Neural Genes
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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