MBP shRNA Plasmid Expression Vector Set

Name: MBP shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY349
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY349]

Target:: MBP

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Product Overview

Description

A comprehensive kit for the specific knockdown of Myelin Basic Protein (MBP), a major structural protein of the myelin sheath. The set provides three validated shRNA plasmid vectors targeting different sequences of the MBP mRNA, along with a non-targeting scrambled shRNA plasmid as a negative control. It is a robust system for modeling demyelination and studying the structural role of MBP.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

MBP

Full Name

Myelin Oligodendrocyte Glycoprotein

Gene ID

4340

Uniprot ID

Q16653

Target Overview

Myelin Oligodendrocyte Glycoprotein (MOG) is a protein located on the surface of oligodendrocytes and the outermost layer of myelin sheaths within the central nervous system. While its precise physiological function is still being fully determined, MOG is critically important in neuropathology as a primary target for the immune system in certain autoimmune demyelinating diseases. The presence of antibodies against MOG is the defining characteristic of MOG antibody disease (MOGAD), an inflammatory condition distinct from multiple sclerosis (MS), and is used as a key diagnostic biomarker.

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