Mouse Anti-Human Dopamine D1 Receptor Monoclonal Antibody (CBP2330)

Product Overview

Description

Dopamine receptors are a family of G protein-coupled receptors, which is composed of at least five (D1-D5) members. The D1 subtype is the most common receptor in the central nervous system. It is primarily expressed in caudate putamen in humans. This receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It plays a role in neuronal growth and development along with behavioral responses. The D1 receptor also modulates D2-mediated events. There are two variants of this gene due to alternate transcription initiation sites.

Immunogen

Human DRD1-transfectants.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2330

Applications

Application Notes

FCM (5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Dopamine D1 Receptor

Official Name

DRD1

Full Name

Dopamine receptor D1

Alternative Names

DRD1; dopamine receptor D1; DADR; DRD1A

Gene ID

1812(Human); 13488(Mouse); 24316(Rat)

Uniprot ID

P21728(Human); Q61616(Mouse); P18901(Rat)

References

1. Fresnoza S, et al. 2014. J. Neurosci. 34(7):2744.
2. Mizuta K, et al. 2013. Respir. Res. 14:89.
3. Zhu F, et al. 2013. PLoS One 8(8):e70805.
4. Levy F, et al. 2013. J. Child Adolesc. Psychopharmacol. 6:423.

Publications