Mouse Anti-Human Gephyrin Monoclonal Antibody (CBP2381)
[CAT#: NAB2010400LS]
Anti-Gephyrin Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Gephyrin (GPHN) is a scaffold protein that anchors glycine and GABA receptors to the tubulin cytoskeleton in the postsynaptic terminal of inhibitory synapses. Gephyrin's function as a scaffolding protein is regulated at transcriptional and translational levels, which impact the formation and plasticity of GABAergic synapses, as well as the overall strength of GABAergic transmission. Low levels of gephyrin in temporal lobe correspond to reduced inhibitory signals and correlate with temporal lobe epilepsy.
Immunogen
Human recombinant gephyrin expressed in human HEK293T cells.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a, κ
Clone Number
CBP2381
Applications
WB; IHC-P; ICC
Application Notes
WB (0.5-5.0 µg/mL); IHC-P (5.0-10.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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