Anti-Doublecortin Monoclonal Antibody (CBP2383)

Product Overview

Description

Doublecortin (DCX) is a microtubule-associated protein that is predominantly expressed in embryonic brains by neuronal precursor cells or immature neurons. DCX is also expressed in the adult brains in regions such as subventricular zones and dentate gyrus, where neuronal precursor cells are localized, and thus has been widely used as a marker for neurogenesis. Doublecortin binds to the microtubule cytoskeleton and stabilizes microtubule bundles. Mutation in DCX has been identified in diseases such as X-linked lissencephaly and double cortex syndrome.

Immunogen

Full-length human recombinant DCX protein produced in HEK293T cell.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2383

Applications

Application Notes

WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Doublecortin

Official Name

DCX

Full Name

doublin or lissencephalin-X

Alternative Names

DCX; DBCN; DC; LISX; SCLH; XLIS; doublecortin

Gene ID

1641(Human); 13193(Mouse); 84394(Rat)

Uniprot ID

O43602(Human); O88809(Mouse); Q9ESI7(Rat)

References

1. Ayanlaja AA, et al. 2017. Front Mol Neurosci. 10:199
2. Reiner O. 2013. Scientifica (Cairo). 2013:393975
3. Reiner O, et al. 2004. Cell Cycle. 3(6):747

Publications