Mouse Anti-Dynamin 1 Monoclonal Antibody (CBP2399)

Product Overview

Description

Dynamin-1, also known as DMN-1, is a 100 kD protein with GTPase activity. Dynamin-1 is involved in several intracellular trafficking processes including synaptic vesicle recycling, neurotransmitter reuptake and receptor internalization. In addition, Dynamin-1 may be necessary for the establishment and proper maintenance of mature neuronal structure. Studies have shown that Dynamin-1 is upregulated during new neurite formation. Conversely, Dynamin-1 is downregulated during neurite retraction. Silencing the initiation codon for Dynamin limits the formation of axon-like structures.

Immunogen

Recombinant human Dynamin-1 (515-750a.a.) expressed in E. coli.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP2399

Applications

WB; IHC-P

Application Notes

WB (0.2-2 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Dynamin 1

Official Name

DNM1

Full Name

Dynamin 1

Alternative Names

DNM1; Dynamin-1; DNM; EIEE31; dynamin 1

Gene ID

1759(Human); 13429(Mouse); 140694(Rat)

Uniprot ID

Q05193(Human); P39053(Mouse); P21575(Rat)

References

1. Obar RA, et al. 1990. Nature. 347:256.
2. Chen-Hwang MC, et al. 2002. J Biol Chem. 277:17597.
3. Grabs D, et al. 1997. J Biol Chem. 272:13419.
4. Wunderlich L, et al. 1999. Cell. Signal. 11:25.

Publications