NeuroMab™ Rat Anti-Human TDP43 Monoclonal Antibody (CBP2480)
[CAT#: NAB2010601LS]
Anti TDP43 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- WB; IHC; IF; ELISA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
TDP43 (aka TARDBP) was originally identified as a protein which binds to the transactivation response (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. TDP43 contains two copies of a ~90 amino acid RNA recognition motif (RRM) found in many proteins which bind single stranded RNA. TDP-43 localizes to the nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. Hyperphosphorylated, ubiquitinated, and cleaved in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a
Clone Number
CBP2480
Applications
WB; IHC; IF; ELISA
Application Notes
WB (1:1000)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1815
Product Properties
Form
Liquid
Formulation
PBS
Concentration
1.0 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Protocols
Protocols
Its related pathways are Neuroscience.
Publications
Publications (0)
Neural Genes
Mouse TAR DNA binding protein (Tardbp) transcript variant 3 (NM_001003899) ORF clone, Myc-DDK Tagged
Mouse TAR DNA binding protein (Tardbp) transcript variant 4 (NM_001008546) ORF clone, Myc-DDK Tagged
Neural Antibodies
Neural Cell Lines
Kits
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