NeuroMab™ Mouse Anti-Apolipoprotein E/APOE Monoclonal Antibody (CBP2519)

Product Overview

Description

Mouse Anti-Human Apolipoprotein E/APOE Monoclonal IgG1, Kappa

Immunogen

Human apoE amino acids 126-191.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, Kappa

Clone Number

CBP2519

Applications

WB; IP; IF; IHC-P

Application Notes

WB: 1/100-1/1000
IP: 1-2ug/100-500ug/ml
IHC: 1/50-1/500
IF: 1/50-1/500

Relevant Diseases

Alzheimer's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1844

Product Properties

Form

Liquid

Formulation

PBS, < 0.1% sodium azide, 0.1% gelatin

Preservatives

YES

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at 4°C, **DO NOT FREEZE**.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Apo E

Official Name

Apoe

Full Name

Apolipoprotein E

Alternative Names

APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4

Gene ID

348 (Human); 11816 (Mouse)

Uniprot ID

P02649 (Human); P08226 (Mouse)

References

1. Choe, L.H., et al. 2002. Apolipoprotein E and other cerebrospinal fluid
proteins differentiate ante mortem variant Creutzfeldt-Jakob disease
from ante mortem sporadic Creutzfeldt-Jakob disease. Electrophoresis
23: 2242-2246.
2. Elam, M.B., et al. 2010. Dysregulation of sterol regulatory element binding
protein-1c in livers of morbidly obese women is associated with altered
suppressor of cytokine signaling-3 and signal transducer and activator of
transcription-1 signaling. Metabolism 59: 587-598.
3. Cerf, E., et al. 2011. High ability of apolipoprotein E4 to stabilize amyloid-β
peptide oligomers, the pathological entities responsible for Alzheimer's
disease. FASEB J. 25: 1585-1595.
4. Darreh-Shori, T., et al. 2011. The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with
butyrylcholinesterase. Neurobiol. Aging 32: 1236-1248.

Publications