TREM2 shRNA Plasmid Expression Vector Set

Name: TREM2 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY332
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY332]

Target:: TREM2

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Product Overview

Description

A specialized kit for the targeted knockdown of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a critical microglial receptor in Alzheimer's disease. The set provides three distinct shRNA plasmid vectors targeting TREM2 mRNA to ensure high knockdown efficiency, plus a scrambled shRNA plasmid as a negative control. It is an essential tool for investigatin

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

TREM2

Full Name

Triggering Receptor Expressed On Myeloid Cells 2

Alternative Names

TREM-2

Gene ID

54209

Uniprot ID

Q9NZC2

Target Overview

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a transmembrane receptor primarily expressed on the surface of myeloid cells, such as microglia, the resident immune cells of the brain. It plays a critical role in regulating microglial activation, survival, and phagocytic activity-the process of clearing cellular debris and protein aggregates like amyloid-beta. Genetic variants of TREM2 are significant risk factors for developing late-onset Alzheimer's disease and other neurodegenerative disorders, making it a key target for therapeutic modulation of the brain's immune response.

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