Product Overview

Description

Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). CgA is one of the most used tumor markers in NET's (neuroendocrine tumors), and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors.

Expression Host

Mammalian cells

Immunogen

Chromogranin A fusion protein Ag0807

Species Reactivity

Human; Rat; Porcine; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2618

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neuron

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Chromogranin A

Official Name

CHGA

Full Name

Chromogranin A

Alternative Names

CGA; CHGA; Chromogranin A; Pituitary secretory protein I; SP I; Vasostatin I Vasostatin

Gene ID

12652(Mouse); 24258(Rat)

Uniprot ID

P26339(Mouse); P10354(Rat)

References

1. Yin, L., Hu, P., Shi, X., Qian, W., Zhau, H. E., Pandol, S. J.,... & Wang, R. (2020). cancer cell's neuroendocrine feature can be acquired through cell-cell fusion during cancer-neural stem cell interaction. Scientific reports, 10(1), 1-13. 2. Hor, P., Punj, V., Calvert, B. A., Castaldi, A., Miller, A. J., Carraro, G.,... & Ryan, A. L. (2020). Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells. iScience, 23(5).

Publications