Mouse Anti-LGALS3 Monoclonal Antibody (CBP2641)

Product Overview

Description

Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose-containing oligosac-charides (PMID: 8063692). Galectin-3, a 31-kDa member of the β-galactoside-binding proteins, contains one carbohydrate recognition domain (CRD) and a proline- and glycine-rich N-terminal domain through which is able to form oligomers (PMID: 14758078). Galectin-3 is widely expressed in many normal tissues and a variety of tumors. It is found intracellularly in nucleus and cytoplasm or secreted outside of cell, being present on the cell surface or in the extracellular space (PMID: 16478649). Galectin-3 is involved in various biological processes including cell growth, adhesion, differentiation, apoptosis, angiogenesis, immune response, neoplastic transformation and metastasis.

Expression Host

Mammalian cells

Immunogen

Galectin-3 fusion protein Ag6753

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2641

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neurotransmission

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

833 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Galectin 3

Official Name

LGALS3

Full Name

Lectin, galactoside-binding, soluble, 3

Alternative Names

35 kDa lectin; CBP 35; CBP35; Gal 3; GAL3; Galactose specific lectin 3; Galactoside binding protein

Gene ID

3959(Human); 19039(Mouse); 245955(Rat)

Uniprot ID

Q08380(Human); Q07797(Mouse); O70513(Rat)

References

1. Yang, Z., Zheng, B., Zhang, Y., He, M., Zhang, X. H., Ma, D.,... & Wen, J. K. (2015). miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(7), 1477-1489. 2. Tian, S., Jiang, C., Liu, X., Xu, S., Zhang, Z., Chen, H.,... & Ma, D. (2017). Hypermethylation of IFN-γ in oral cancer tissues. Clinical oral investigations, 21(8), 2535-2542. 3. Jiang, W., Zheng, B., Zhang, X. H., Yue, L. Y., Liu, C., Ma, D.,... & Wen, J. K. (2016). Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages. American journal of translational research, 8(11), 4778.

Publications