Mouse Anti-NEFH Monoclonal Antibody (CBP2670)

Product Overview

Description

NEFH belongs to the intermediate filament family. It has an important function in mature axons that is not subserved by the two smaller NF proteins. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Expression Host

Mammalian cells

Immunogen

NF-H fusion protein Ag13517

Species Reactivity

Human; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2670

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1500 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NEFH

Official Name

NEFH

Full Name

Neurofilament, heavy polypeptide

Gene ID

4744(Human); 380684(Mouse); 24587(Rat)

Uniprot ID

P12036(Human); P19246(Mouse); P16884(Rat)

References

1. Liu, H., Yang, H., Fang, Y., Li, K., Tian, L., Liu, X.,... & Lin, B. (2020). Neurotoxicity and biomarkers of zinc oxide nanoparticles in main functional brain regions and dopaminergic neurons. Science of The Total Environment, 705, 135809.

Publications