Mouse Anti-LIN28 Monoclonal Antibody (CBP2674)

Product Overview

Description

LIN28 is one of the four key human factors (OCT4, SOX2, NANOG and LIN28) used to reprogram human fibroblasts to an embryonic stem (ES) cell-like state known as the induced pluripotent stem (Ips) cell. Lin28 is a marker of undifferentiated human embryonic stem cells and a cytoplasmic Mrna-binding protein that binds to and enhances the translation of the IGF2 Mrna. LIN28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells.

Expression Host

Mammalian cells

Immunogen

LIN28 fusion protein Ag2312

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2674

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1560 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

LIN28A

Official Name

LIN28A

Full Name

Lin-28 homolog

Alternative Names

CSDD1; LIN 28; lin 28 homolog (C. elegans); Lin 28A; LIN28; Lin28A; Protein lin 28 homolog A; ZCCHC1

Gene ID

79727(Human)

Uniprot ID

Q9H9Z2(Human)

References

1. Hara-Yokoyama, M., Kurihara, H., Ichinose, S., Matsuda, H., Ichinose, S., Kurosawa, M.,... & Furukawa, K. (2019). KIF11 as a potential marker of spermatogenesis within mouse seminiferous tubule cross-sections. Journal of Histochemistry & Cytochemistry, 67(11), 813-824. 2. He, W., Liang, B., Wang, C., Li, S., Zhao, Y., Huang, Q.,... & Zhang, S. (2019). MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene, 38(23), 4637-4654.

Publications