Mouse Anti-ARG1 Monoclonal Antibody (CBP2696)

Product Overview

Description

ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.

Expression Host

Mammalian cells

Immunogen

ARG1 fusion protein Ag8810

Species Reactivity

Human; Porcine; Rat; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2696

Applications

IHC; IP; WB; ELISA

Application Notes

IHC : 1:20-1:200; IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Arginase 1

Official Name

ARG1

Full Name

Arginase, liver

Alternative Names

ARG1; Arginase 1; liver Arginase; Liver type arginase

Gene ID

11846(Mouse); 29221(Rat)

Uniprot ID

Q61176(Mouse); P07824(Rat)

References

1. Wu, J., Ding, D. H., Li, Q. Q., Wang, X. Y., Sun, Y. Y., & Li, L. J. (2019). Lipoxin A4 regulates lipopolysaccharide-induced BV2 microglial activation and differentiation via the Notch signaling pathway. Frontiers in cellular neuroscience, 13, 19. 2. Zhang, H. Y., Chen, R. L., Shao, Y., Wang, H. L., & Liu, Z. G. (2018). Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring. Toxicology research, 7(5), 809-816. 3. Xu, C., Diao, Y. F., Wang, J., Liang, J., Xu, H. H., Zhao, M. L.,... & Wei, M. G. (2020). Intravenously infusing the secretome of adipose-derived mesenchymal stem cells ameliorates neuroinflammation and neurological functioning after traumatic brain injury. Stem Cells and Development, 29(4), 222-234.

Publications