Mouse Anti-CTNNB1 Monoclonal Antibody (CBP2757)

Product Overview

Description

β-Catenin is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers.

Expression Host

Mammalian cells

Immunogen

Peptide

Species Reactivity

Human; Mouse; Rat; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2757

Applications

IF; IHC; IP; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Neuron

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CTNNB1

Official Name

CTNNB1

Full Name

Catenin (cadherin-associated protein), beta 1, 88kDa

Alternative Names

b cat; Beta catenin; beta-Catenin; Catenin beta 1; CTNNB; CTNNB1; PRO2286; β catenin; β-catenin

Gene ID

1499(Human); 12387(Mouse); 84353(Rat)

Uniprot ID

P35222(Human); Q02248(Mouse); Q9WU82(Rat)

References

1. Li, B., Cao, Y., Meng, G., Qian, L., Xu, T., Yan, C.,... & Yu, D. (2019). Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine, 39, 239-254. 2. Yan, L., You, W. Q., Sheng, N. Q., Gong, J. F., Hu, L. D., Tan, G. W.,... & Wang, Z. G. (2018). A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer. Aging (Albany NY), 10(12), 3774. 3. Xie, L., Li, M., Liu, D., Wang, X., Wang, P., Dai, H.,... & Zhao, M. (2019). Secalonic Acid-F, a Novel Mycotoxin, represses the progression of hepatocellular carcinoma via MARCH1 regulation of the PI3K/AKT/β-catenin signaling pathway. Molecules, 24(3), 393.

Publications