Mouse Anti-BIRC5 Monoclonal Antibody (CBP2787)

Description

Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.

Expression Host

Mammalian cells

Immunogen

SURVIVIN fusion protein Ag20958

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2787

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

BIRC5

Official Name

BIRC5

Full Name

Baculoviral IAP repeat-containing 5

Alternative Names

API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; EPR 1; IAP4; SURVIVIN

Gene ID

332(Human)

Uniprot ID

O15392(Human)

1. Gu, J., Ji, Z., Li, D., & Dong, Q. (2019). Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma. Acta biochimica et biophysica Sinica, 51(1), 59-67.