Mouse Anti-IDE Monoclonal Antibody (CBP2905)

Product Overview

Description

IDE(INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid. The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism. It can exsit as a homodimer and form higher oligomers.

Expression Host

Mammalian cells

Immunogen

IDE fusion protein Ag17161

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2905

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Insulin Degrading Enzyme

Official Name

IDE

Full Name

Abeta degrading protease

Alternative Names

Abeta-degrading protease;
FLJ35968;
Ide;
IDE_HUMAN;
Insulin protease;
Insulin-degrading enzyme;
Insulinase;
Insulysin;

Gene ID

3416(Human); 15925(Mouse); 25700(Rat)

Uniprot ID

P14735(Human); Q9JHR7(Mouse); P35559(Rat)

References

1. Zhou, L., Liao, W., Zeng, H., Yao, Y., Chen, X., & Ding, K. (2018). A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing. Carbohydrate polymers, 201, 65-74.

Publications