Anti-CD200 Monoclonal Antibody (CBP3847)

Product Overview

Description

CD200, also known as OX2, is a member of the immunoglobulin superfamily (IgSF). It is a monomorphic cell surface glycoprotein, expressed in thymocytes, neurons, endothelium, follicular dendritic cells, some CD34+ progenitor cells of all lymphoid organs, and on some smooth muscles and B lymphocytes Low-level expression. It is not expressed on NK cells, monocytes, granulocytes or platelets. CD200 co-stimulates T cell proliferation. It can regulate the activity of myeloid cells in a variety of tissues. The interaction between the CD200 (OX2) and CD200 receptor (OX2R) systems is important in controlling the activation of macrophages and granulocytes, which may help to inhibit and limit the pathways for macrophages to cause inflammatory damage in tissues.

Species Reactivity

Human; African green monkey; Baboon

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3847

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD200

Official Name

CD200

Full Name

OX-2 membrane glycoprotein

Alternative Names

CD200; CD200 molecule; MOX1; MOX2; MRC; OX-2; CD-200

Gene ID

4345 (Human); 17470 (Mouse)

Uniprot ID

P41217 (Human); O54901 (Mouse)

References

1. Wright GJ, et al. 2001. Immunology. 102:173.
2. Foster-Cuevas M, et al. 2004. J. Virol. 78:7667.
3. Mason D, et al. 2002. ed. Leukocyte Typing VII. New York:Oxford Univ. Press.
4. Broderick C, et al. 2002. Am. J. Pathol. 161:1669.

Publications