Anti-CD200R Monoclonal Antibody (CBP3854)

Product Overview

Description

CD200R, also known as OX2R, is a membrane glycoprotein, 70% of its weight comes from N-linked glycosylation. CD200R is mainly expressed by monocytes and neutrophils, but it is also expressed by other white blood cells (including T cells and mast cells). The interaction between CD200 and CD200R may help inhibit and limit the pathways of tissue inflammatory damage induced by macrophages.

Immunogen

Human CD200R full length fusion protein

Species Reactivity

Human; Baboon

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3854

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.2 µm filtered in PBS, pH 7.2, containing no preservative.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD200

Official Name

CD200

Full Name

OX-2 membrane glycoprotein

Alternative Names

CD200; CD200 molecule; MOX1; MOX2; MRC; OX-2; CD-200

Gene ID

4345 (Human); 17470 (Mouse)

Uniprot ID

P41217 (Human); O54901 (Mouse)

References

1. Wright GJ, et al. 2001. Immunology. 102:173.
2. Foster-Cuevas M, et al. 2004. J. Virol. 78:7667.
3. Mason D, et al. 2002. ed. Leukocyte Typing VII. New York:Oxford Univ. Press.
4. Broderick C, et al. 2002. Am. J. Pathol. 161:1669.

Publications