Mouse Anti-Human MMP-1 Monoclonal Antibody (CBP3875)

[CAT#: NAB2012433LS]

Anti-MMP-1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

MMP1 consists of a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin-like repeats) domain. It is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.

Immunogen

Recombinant human MMP-1.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3875

Applications

Application Notes

WB (1.0-1.25 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MMP-1

Official Name

MMP1

Full Name

Matrix metalloproteinase-1

Alternative Names

MMP1; CLG; CLGN; matrix metallopeptidase 1

Gene ID

4312 (Human); 83995 (Mouse)

Uniprot ID

P03956 (Human); Q9EPL5 (Mouse)

References

1. Nagase H and Woessner JF Jr. 1999. J. Biol. Chem. 274:21491.
2. Boire A, et al. 2005. Cell 120:303.
3. Kader AK, et al. 2007. Clin. Cancer Res. 13:2614.
4. Gill SE and Parks WC. 2008. Int. J. Biochem. Cell Biol. 40:1334.
5. Mazor R, et al. 2013. J. Biol. Chem. 288:598.
6. Sommer K, et al. 2013. PLos One 8:e73992.

Publications