Anti-Synaptophysin Monoclonal Antibody (CBP3947)

Product Overview

Description

Synaptophysin, also known as major synaptic vesicle protein P38, is encoded by the SYP gene in humans and is located on the short arm of the X chromosome. Synaptophysin is a 38 kD protein that contains four transmembrane domains. Synaptophysin is a synaptic vesicle glycoprotein, and interacts with synaptobrevin. It has been implicated in X-linked mental retardation and can be used as a specific marker for cells of the adrenal medulla and pancreatic islets. As such, it can be used to identify tumors that are derived from those cells, including neuroblastoma, retinoblastoma, medulloblastoma, and others.

Immunogen

A crude synaptic preparation from post mortem human brain.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgM, κ

Clone Number

CBP3947

Applications

WB; IHC-P; ICC; ELISA

Application Notes

WB (1:1000-1:5000); IHC (1:1000-1:5000); ICC (1:1000-1:5000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

Ascites Fluid (contains 0.01M sodium azide).

Concentration

Batch Dependent

Purification

Unpurified

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at-20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Synaptophysin

Official Name

SYP

Full Name

Synaptophysin

Alternative Names

C5AR1

References

1. Zhang L, et al. 2018. Medicine (Baltimore). 97(29):e11487
2. Moris, et al. 2018. Anticancer res. 38(2):601
3. Hami J, et al. 2017. J pediatr Neurosci. 12(3):215

Publications