Anti-Spastin Monoclonal Antibody (CBP3948)

Product Overview

Description

Spastin is a microtubule-severing protein that cleaves longer microtubules (MTs) to shorter ones. The severing of MT regulates its numbers and mobility, and the distribution of the plus-end. This has also been related to membrane trafficking of microtubules. Mutations in the spastin gene SPG4 is the main cause for hereditary spastic paraplegia, a neurodegenerative disorder mainly occurring in corticospinal tracks. Due to the presence of 2 start codons in SPG4 gene, 2 isoforms of spastin exist: a 68 kD isoform termed M1 and a 60 kD isoform termed M87. The M1 isoform is only detected in the adult spinal cord while the M87 isoform is ubiquitously expressed.

Immunogen

Recombinant human spastin protein

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP3948

Applications

Application Notes

WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Spastin

Official Name

SPAST

Full Name

Spastin

Alternative Names

C5AR1

References

1. Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.

1. Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.

Publications