Product
Anti-Spastin Monoclonal Antibody (CBP3948)
[CAT#: NAB2012864LS]
Anti-Spastin Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Spastin is a microtubule-severing protein that cleaves longer microtubules (MTs) to shorter ones. The severing of MT regulates its numbers and mobility, and the distribution of the plus-end. This has also been related to membrane trafficking of microtubules. Mutations in the spastin gene SPG4 is the main cause for hereditary spastic paraplegia, a neurodegenerative disorder mainly occurring in corticospinal tracks. Due to the presence of 2 start codons in SPG4 gene, 2 isoforms of spastin exist: a 68 kD isoform termed M1 and a 60 kD isoform termed M87. The M1 isoform is only detected in the adult spinal cord while the M87 isoform is ubiquitously expressed.
Immunogen
Recombinant human spastin protein
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a, κ
Clone Number
CBP3948
Applications
WB
Application Notes
WB (5.0-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
Spastin
Official Name
SPAST
Full Name
Spastin
Alternative Names
C5AR1
References
1. Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.
1. Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.
1. Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
2. Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
