Rabbit Anti-Human Ferritin Light Chain Monoclonal Antibody (CBP4244)
[CAT#: NAB210111LS]
Anti-Ferritin Light Chain Monoclonal Antibody
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Ferritin is a ubiquitously expressed protein that controls iron storage and releases in a non-toxic form. The majority of ferritin in vivo is cytoplasmic, although iron-binding ferritin is also secreted into the serum. Clinically, plasma/serum ferritin has been used as a marker for total iron detection in the body, and thus could function as a diagnostic tool for iron-deficiency and anemia. Dysregulation of iron in the brain has been linked to Alzheimer's disease. Recent studies have shown that ferritin light chain interacts with presenilin enhancer 2 (PEN-2) affecting its γ-secretase activity, which impacts amyloid beta (Aβ) production and deposition.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rabbit
Isotype
IgG
Clone Number
CBP4244
Applications
WB; IHC-P
Application Notes
WB (0.05-0.2 µg/mL); IHC-P ( 0.1 - 2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Morris G, et al. 2018. Behav Brain Res. 341:154.
2. Philpott CC, et al. 2017. J Biol Chem. 292(31):12764.
2. Philpott CC, et al. 2017. J Biol Chem. 292(31):12764.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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