Mouse Anti-Rat CSTB Monoclonal Antibody (CBP4262)

[CAT#: NAB210132LS]

Anti-CSTB Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Rat

Applications:: WB

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Product Overview

Description

Cystatin B (CSTB) is a type 1 cystatin belonging to the cystatin superfamily. There are three cystatin subfamilies including type 1 cystatins, type 2 cystatins, and kininogens. Cystatins are thought to have a protective role against the proteases that leak from the lysosomes by inhibiting their cysteine proteinase activity. CSTB can covalently form dimers, tetramers, or oligomers. CSTB oligomers bind to aggregated amyloid-beta (Aβ) and reduce Aβ fibril formation.

Immunogen

Recombinant rat CSTB (amino acid sequence Met2~Phe98)

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4262

Applications

Application Notes

WB (0.1-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.