Mouse Anti-VCP Monoclonal Antibody (CBP4290)

Product Overview

Description

Valocin-containing protein (VCP) is a member of a family of proteins that include putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP associates with clathrin and heat-shock protein Hsc70 to form a complex that functions as a chaperon to unfold and transport proteins to different cellular compartments. Diseases associated with VCP include inclusion body myopathy with early-onset Paget's disease, and frontotemporal dementia 1 and amyotrophic lateral sclerosis 14, with or without frontotemporal dementia.

Immunogen

Recombinant Human VCP Protein

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4290

Applications

WB; IHC-P

Application Notes

WB ( 0.5- 2.0 µg/mL); IHC-P (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.