Mouse Anti-HDAC2 Monoclonal Antibody (CBP4324)

Product Overview

Description

HDAC2 is a member of class I histone deacetylase (HDACs) family, which modulates the chromatin structure by removing acetyl groups (deacetylation) from the side chain of lysine residues on the N-terminal region of core histones (H2A, H2B, H3 and H4). Generally, histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Immunogen

This monoclonal antibody was raised against a peptide sequence derived from the C-terminus of the human HDAC2 protein.

Species Reactivity

Human; Rat; Drosophila

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP4324

Applications

Application Notes

WB (1-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

HDAC2

Official Name

HDAC2

Full Name

Histone Deacetylase 2

Alternative Names

Histone Deacetylase 2; EC 3.5.1.98; HD2; Transcriptional Regulator Homolog RPD3; YY1-Associated Factor 1; RPD3; YAF1

Gene ID

3066(Human); 15182(Mouse); 84577(Rat)

Uniprot ID

Q92769(Human); P70288(Mouse)

References

1. Winter M, et al. 2013. EMBO J. 32:3176.
2. Ma P, et al. 2013. PLoS Genet. 9:e1003377.
3. Kurita M, et al. 2012. Nat. Neurosci. 15:1245.
4. Segre CV, et al. 2011. J. Biomed. Biotechnol. 2011:690848.
5. Brunmeir R, et al. 2009. Int. J. Dev. Biol. 53:275.
6. Guan JS, et al. 2009. Nature 459:55.

Publications