Mouse Anti-Human FXR1 Monoclonal Antibody (CBP4327)

[CAT#: NAB2101106LS]

Anti-FXR1 Monoclonal Antibody [HRP]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

FXR1 is an RNA binding protein that interacts with polyribosomes, specifically with the 60S ribosome subunit. In the adult brain, FXR1 is mainly localized to the cytoplasm and the proximal dendrites of neurons. In the fetal brain, FXR1 is expressed in the nucleus of neurons. Clinically, FXR1 mutations have been identified as a major genetic contributing factor to fragile X mental retardation syndrome. Recent studies also suggest that FXR family of proteins integrate dopamine signaling and glutamatergic neurotransmission.

Immunogen

Recombinant human FXR1

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP4327

Applications

Application Notes

WB (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

HRP

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

FXR1

Official Name

FXR1

Full Name

Fragile X mental retardation syndrome-related protein 1

Alternative Names

FXR1; FXR1P; FMR1 autosomal homolog 1; MYORIBF; MYOPMIL

Gene ID

8087

Uniprot ID

P51114

References

1. Khlghatyan J, Beaulieu JM. 2018. Front Synaptic. Neurosci. 10:22.
2. Bardoni B, et al. 2001. Brain Res. Bull. 56:375-82.
3. Inoue SB, et al. 2000. J. Med. Invest. 47(3-4):101.

Publications