Parkin shRNA Plasmid Expression Vector Set

Name: Parkin shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY336
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY336]

Target:: Parkin

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Product Overview

Description

A complete kit for the specific knockdown of the Parkin (PARK2) gene, an E3 ubiquitin ligase commonly mutated in early-onset Parkinson's disease. The set includes three distinct shRNA plasmid vectors targeting Parkin mRNA, plus a non-targeting scrambled shRNA plasmid as a negative control. It is essential for investigating Parkin's critical role in mitophagy and mitochondrial quality control.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

Parkin

Full Name

E3 Ubiquitin-Protein Ligase Parkin

Alternative Names

PRKN

Gene ID

5071

Uniprot ID

O60260

Target Overview

Parkin is a crucial E3 ubiquitin ligase, an enzyme that attaches ubiquitin tags to other proteins to mark them for degradation by the cell's proteasome system. It plays a vital role in cellular quality control, most notably in a process called mitophagy, which is the selective clearance of damaged or dysfunctional mitochondria. Loss-of-function mutations in the PARK2 gene, which codes for the Parkin protein, are the most common cause of autosomal recessive, early-onset Parkinson's disease. The resulting failure of the mitophagy pathway is thought to lead to the accumulation of toxic, damaged mitochondria and subsequent death of dopamine-producing neurons.

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