tPA shRNA Plasmid Expression Vector Set

Name: tPA shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY360
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY360]

Target:: tPA

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Product Overview

Description

A specialized kit for the specific knockdown of tissue Plasminogen Activator (tPA). The set provides three distinct shRNA plasmid vectors targeting tPA mRNA for potent silencing, along with a scrambled shRNA plasmid as a negative control. It allows researchers to study tPA's dual role in fibrinolysis and its effects on the blood-brain barrier and excitotoxicity.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

tPA

Full Name

Vascular Endothelial Growth Factor A

Gene ID

7422

Uniprot ID

P15692

Target Overview

Vascular Endothelial Growth Factor A (VEGF-A) is the primary signaling protein responsible for stimulating angiogenesis-the formation of new blood vessels. It is essential for normal physiological processes such as embryonic development, bone formation, and wound healing. However, VEGF-A is also a critical factor in pathology. It is overexpressed by many tumors, which hijack its function to create new blood vessels that supply them with nutrients and oxygen, thereby enabling tumor growth and metastasis. It also drives abnormal vessel growth in eye diseases like wet age-related macular degeneration, making it a major therapeutic target.

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